Research progress of tPA / 医学研究生学报

ABSTRACT

Tissue-type plasminogen activator (tPA) belongs to the serine protease family, which is expressed in most organs, including the brain and spinal cord.tPA plays an important role in the removal of intravascular fibrin deposition and has been approved for thrombolytic therapy for acute cerebral ischemia .In the central nervous system (CNS), tPA displays many important functions, such as neuronal survival or death , synaptic plasticity, and learning and memory processes .tPA can be synthesized by many types of cells, so it has additional functions besides the blood vessels and CNS .In this review, we provide the structural features , the role in cerebral ischemia, and other functions of tPA.