Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis
Laboratory Medicine Online
; : 41-51, 2018.
Article
ي En
| WPRIM
| ID: wpr-713889
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
Natural killer (NK) cells play a key role in innate immune responses and are an important component of anti-cancer defenses. This study aimed to investigate the clinicopathological characteristics of NK cell activity (NKA) among various hematological malignancies at diagnosis and to evaluate their clinical value as a monitoring marker.METHODS:
A total of 111 patients that were newly diagnosed with hematological malignancies were recruited, comprising 18 acute myeloid leukemia (AML), 31 multiple myeloma (MM), and 62 lymphoma. Twenty-three normal control subjects from our health examination center were recruited. NKA was measured using a commercially available enzyme-linked immunosorbent assay kit, which measures interferon-gamma secreted by ex vivo-stimulated NK cells in whole blood.RESULTS:
The 111 patients had a median NKA of 202.80 pg/mL (range 40–2,000). NKA was significantly decreased in patients with AML (median 47.05 pg/mL, 40–2,000, P<0.0001), MM (275.00, 40–2,000, P<0.0001), and lymphoma (289.49, 40–2,000, P<0.0001) compared with that in normal controls (1,891, 412–2,000). There was a difference in NKA between AML and lymphoma (P=0.0499). Serial changes in NKA correlated with disease progression. NKA did not correlate with the NK cell count in any group of hematological malignancies.CONCLUSIONS:
The measurement of NKA could be useful to evaluate the immunological status in hematological malignancies at diagnosis and during follow-up.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Enzyme-Linked Immunosorbent Assay
/
Killer Cells, Natural
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Leukemia, Myeloid, Acute
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Follow-Up Studies
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Interferon-gamma
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Disease Progression
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Hematologic Neoplasms
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Diagnosis
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Immunity, Innate
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Lymphoma
نوع الدراسة:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
المحددات:
Humans
اللغة:
En
مجلة:
Laboratory Medicine Online
السنة:
2018
نوع:
Article