Underregistration and Underreporting of Stem Cell Clinical Trials in Neurological Disorders
Journal of Clinical Neurology
; : 215-224, 2018.
Article
ي En
| WPRIM
| ID: wpr-714332
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Research on stem cells (SC) is growing rapidly in neurology, but clinical applications of SC for neurological disorders remain to be proven effective and safe. Human clinical trials need to be registered in registries in order to reduce publication bias and selective reporting.METHODS:
We searched three databases—clinicaltrials.gov, the Clinical Research Information System (CRIS), and PubMed—for neurologically relevant SC-based human trials and articles in Korea. The registration of trials, posting and publication of results, and registration of published SC articles were examined.RESULTS:
There were 17 completed trials registered at clinicaltrials.gov and the CRIS website, with results articles having been published for 5 of them. Our study found 16 publications, of which 1 was a review article, 1 was a protocol article, and 8 contained registered trial information.CONCLUSIONS:
Many registered SC trials related to neurological disorders are not reported, while many SC-related publications are not registered in a public registry. These results support the presence of biased reporting and publication bias in SC trials related to neurological disorders in Korea.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Publications
/
Stem Cells
/
Information Systems
/
Bias
/
Registries
/
Publication Bias
/
Korea
/
Nervous System Diseases
/
Neurology
نوع الدراسة:
Guideline
المحددات:
Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Journal of Clinical Neurology
السنة:
2018
نوع:
Article