Usefulness of Two-Step Algorithm with Earlier Growth Detection in Anaerobic Bottle and Time to Positivity to Predict Candida glabrata Fungemia / 대한임상미생물학회지
Annals of Clinical Microbiology
; : 23-27, 2018.
Article
ي En
| WPRIM
| ID: wpr-715236
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
Fast identification of Candida glabrata is important, because empirical antifungal therapy for fungemia with C. glabrata and non-C. glabrata varies. We proposed an algorithm for rapid presumptive diagnosis to identify fungemia with C. glabrata using earlier or only growth from anaerobic bottles and longer time to positivity (TTP) in blood cultures.METHODS:
Positivity and TTP using the BacT/Alert 3D system (bioMerieux Inc, USA) with resin bottles (FA Plus and FN Plus) were analyzed in 215 candidemia patients from June 2014 to June 2016 in a university-affiliated hospital in Korea.RESULTS:
A higher proportion of earlier or only growth from anaerobic bottles was observed in C. glabrata (38.8%, 7/18) than in C. albicans (7.6%, 8/105), C. parapsilosis (10.5%, 4/138), and C. tropicalis (9.2%, 5/54) (P=0.006). The mean (±standard deviation) TTP for C. glabrata was 41.7 h (±16.3 h) compared with 26.7 h (±15.9 h) for C. albicans, 33.4 h (±8.4 h) for C. parapsilosis, and 23.1 h (±17.3 h) for C. tropicalis (P 31.4 h.CONCLUSION:
This two-step algorithm in the BacT/Alert 3D system could be the basis for an initial empirical antifungal therapy for fungemia with C. glabrata prior to final identification.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Candida
/
Sensitivity and Specificity
/
Fungemia
/
Candida glabrata
/
Diagnosis
/
Candidemia
/
Korea
نوع الدراسة:
Diagnostic_studies
/
Prognostic_studies
المحددات:
Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Annals of Clinical Microbiology
السنة:
2018
نوع:
Article