Dose Estimation Curves Following In Vitro X-ray Irradiation Using Blood From Four Healthy Korean Individuals
Annals of Laboratory Medicine
; : 91-95, 2019.
Article
ي En
| WPRIM
| ID: wpr-719473
المكتبة المسؤولة:
WPRO
ABSTRACT
Cytogenetic dosimetry is useful for evaluating the absorbed dose of ionizing radiation based on analysis of radiation-induced chromosomal aberrations. We created two types of in vitro dose-response calibration curves for dicentric chromosomes (DC) and translocations (TR) induced by X-ray irradiation, using an electron linear accelerator, which is the most frequently used medical device in radiotherapy. We irradiated samples from four healthy Korean individuals and compared the resultant curves between individuals. Aberration yields were studied in a total of 31,800 and 31,725 metaphases for DC and TR, respectively, obtained from 11 X-ray irradiation dose-points (0, 0.05, 0.1, 0.25, 0.5, 0.75, 1, 2, 3, 4, and 5 Gy). The dose-response relationship followed a linear-quadratic equation, Y=C+αD+βD², with the coefficients C=0.0011 for DC and 0.0015 for TR, α=0.0119 for DC and 0.0048 for TR, and β=0.0617 for DC and 0.0237 for TR. Correlation coefficients between irradiation doses and chromosomal aberrations were 0.971 for DC and 0.6 for TR, indicating a very strong and a moderate correlation, respectively. This is the first study implementing cytogenetic dosimetry following exposure to ionizing X-radiation.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Particle Accelerators
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Radiation, Ionizing
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Radiotherapy
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In Vitro Techniques
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Calibration
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Chromosome Aberrations
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Cytogenetics
اللغة:
En
مجلة:
Annals of Laboratory Medicine
السنة:
2019
نوع:
Article