Long-term outcome of isolated thrombocytopenia accompanied by hypocellular marrow
Korean Journal of Hematology
; : 128-134, 2011.
Article
ي En
| WPRIM
| ID: wpr-720300
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: Hypocellularity of bone marrow (BM), not associated with significant dyshematopoiesis, is often found in patients with isolated thrombocytopenia, but its clinical implications have not been studied. We prospectively studied the clinical features and natural history of these patients. METHODS: Adults with isolated thrombocytopenia (platelet counts 50x10(9)/L in 16 patients (80%). BM cellularity ranged from 5% to 25% (median, 15%) and was 150x10(9)/L) after 12, 56 and 66 months. Three patients developed pancytopenia after 11, 70 and 90 months. Two patients were consistent with moderate aplastic anemia, and 1 was confirmed as having refractory cytopenia with multilineage dysplasia. In the remainder of the patients, platelet counts remained unchanged. CONCLUSION: Isolated thrombocytopenia accompanied by hypocellular marrow encompasses a group of heterogeneous conditions.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pancytopenia
/
Platelet Count
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Thrombocytopenia
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Bone Marrow
/
Myelodysplastic Syndromes
/
Prospective Studies
/
Follow-Up Studies
/
Chromosome Aberrations
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Purpura, Thrombocytopenic, Idiopathic
/
Natural History
نوع الدراسة:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Adult
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Aged
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Humans
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Male
اللغة:
En
مجلة:
Korean Journal of Hematology
السنة:
2011
نوع:
Article