Reduced Intensity Conditioning Regimen Followed by Allogeneic Peripheral Blood Stem Cell Transplantation for Acute Panmyelosis with Myelofibrosis
Korean Journal of Hematology
; : 266-270, 2005.
Article
ي Ko
| WPRIM
| ID: wpr-720594
المكتبة المسؤولة:
WPRO
ABSTRACT
A 44-year-old male presented with a month history of exertional dyspnea and dizziness. A peripheral blood smear revealed a pancytopenia with 3% of blasts. We were not able to obtain a bone marrow aspirate, but a biopsy specimen showed hypercellularity, proliferation of trilineage cell lines (panmyelosis) with extensive myelofibrosis, and clusters of immature cells at the paratrabecular area. After remission induction therapy with idarubicin 12mg/m2 (D1-3) and cytosine arabinoside 100mg/m2 (D1-7), the bone marrow blast count was decreased, but the marrow fibrosis and pancytopenia persisted. Peripheral blood stem cell transplantation from his HLA-matched brother was performed after administering fludarabine 30mg/m2 for 5 days and busulfan 3.2mg/kg for 2 days. Early engraftment occurred and the bone marrow reticulin fibrosis disappeared. Full-donor chimerism was demonstrated at day 22 by performing short tandem repeats analysis and this was maintained for 1 year. The patient has survived 20 months after transplantation without any complication.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pancytopenia
/
Reticulin
/
Biopsy
/
Bone Marrow
/
Fibrosis
/
Remission Induction
/
Busulfan
/
Idarubicin
/
Cell Line
/
Microsatellite Repeats
المحددات:
Adult
/
Humans
/
Male
اللغة:
Ko
مجلة:
Korean Journal of Hematology
السنة:
2005
نوع:
Article