Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
The Korean Journal of Physiology and Pharmacology
; : 177-182, 2014.
Article
ي En
| WPRIM
| ID: wpr-727678
المكتبة المسؤولة:
WPRO
ABSTRACT
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Risk Factors
/
Rats, Wistar
/
Simvastatin
/
Endocrine System
/
Diet, High-Fat
/
Homocysteine
/
Immune System
/
Nervous System
نوع الدراسة:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Animals
/
Humans
/
Male
اللغة:
En
مجلة:
The Korean Journal of Physiology and Pharmacology
السنة:
2014
نوع:
Article