Effects of Thyrotropin Suppression on Bone Health in Menopausal Women with Total Thyroidectomy
Journal of Bone Metabolism
; : 31-38, 2019.
Article
ي En
| WPRIM
| ID: wpr-740477
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: This study examined the change in the trabecular bone score (TBS), areal bone mineral density (aBMD), and osteoporosis in postmenopausal women who underwent thyrotropin (TSH)-suppressive therapy for treating papillary thyroid cancer after a total thyroidectomy procedure. METHODS: We evaluated 36 postmenopausal women who received a total thyroidectomy for papillary thyroid cancer and were undergoing TSH suppressive therapy with levothyroxine. Postmenopausal women (n=94) matched for age and body mass index were recruited as healthy controls. The aBMD and TBS of the lumbar spine were compared between dual energy X-ray absorptiometry (DXA) at baseline and at follow-up after an average of 4.92 years. RESULTS: There was no significant difference in the rate of diagnoses of osteoporosis, osteopenia, or normal bone status between the 2 groups during the baseline DXA evaluation. However, the TBS was significantly lower whereas aBMD did not show significant difference at the time of baseline DXA measurement (1st DXA, 1.343±0.098 vs. 1.372±0.06317, P < 0.001; 2nd DXA, 1.342±0.095 vs. 1.370±0.062, P < 0.001). The TBS and aBMD did not differ significantly between the initial and follow-up DXA images in both groups of TSH suppressive patients and controls. CONCLUSIONS: The average value of TBS and aBMD did not significantly change during the follow-up period. The TSH suppressive therapy was revealed as not a significant factor for the progressive deterioration of bone status during long term follow-up.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Osteoporosis
/
Spine
/
Thyroidectomy
/
Thyroxine
/
Bone Diseases, Metabolic
/
Thyroid Neoplasms
/
Thyrotropin
/
Absorptiometry, Photon
/
Body Mass Index
/
Bone Density
نوع الدراسة:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
المحددات:
Female
/
Humans
اللغة:
En
مجلة:
Journal of Bone Metabolism
السنة:
2019
نوع:
Article