Prostatectomy Provides Better Symptom-Free Survival Than Radiotherapy Among Patients With High-Risk or Locally Advanced Prostate Cancer After Neoadjuvant Hormonal Therapy
Korean Journal of Urological Oncology
; : 126-134, 2018.
Article
ي En
| WPRIM
| ID: wpr-741479
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE: The purpose of this study is to compare the radiation therapy (RT) and radical prostatectomy (RP) of high-risk or locally advanced prostate cancer (PC) patients after neoadjuvant hormonal therapy (NHT). MATERIALS AND METHODS: This retrospective study evaluated patients underwent RT (42 patients) or RP (152 patients) after NHT at a single center during 2003–2014. Times to biochemical recurrence (BCR), pelvic local recurrence (PLR), metastasis, clinical painful symptom progression (CPSP), castration-resistant PC (CRPC), and overall survival were compared between the RT and RP groups, after adjustment for TN stage, using the Kaplan-Meier method and log-rank test. RESULTS: Significant inter-group differences were observed for age, Gleason score, initial PSA, and clinical and pathological T stages (all p 0.05). The independent predictor of CPSP was RP (hazard ratio, 0.291; p=0.013). CONCLUSIONS: Despite significantly different baseline parameters, RP provided better CPSP-free survival than RT among patients with localized high-risk or locally advanced PC.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prostate
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Prostatectomy
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Prostatic Neoplasms
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Radiotherapy
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Recurrence
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Incidence
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Retrospective Studies
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Risk Factors
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Follow-Up Studies
/
Neoplasm Grading
نوع الدراسة:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
En
مجلة:
Korean Journal of Urological Oncology
السنة:
2018
نوع:
Article