Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica
Natural Product Sciences
; : 259-265, 2018.
Article
ي En
| WPRIM
| ID: wpr-741632
المكتبة المسؤولة:
WPRO
ABSTRACT
The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (IC₅₀s, 39.94 µg/ml for AChE and 86.98 µg/ml for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Plants
/
Butyrylcholinesterase
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Cholinesterases
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Chromatography, High Pressure Liquid
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Lamiaceae
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Stachys
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Alzheimer Disease
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Glycosides
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Memory
اللغة:
En
مجلة:
Natural Product Sciences
السنة:
2018
نوع:
Article