Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery?
Obstetrics & Gynecology Science
; : 88-94, 2018.
Article
ي En
| WPRIM
| ID: wpr-741725
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE: To detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery. METHODS: We retrospectively reviewed 120 patients who underwent radical hysterectomy and pelvic lymphadenectomy as treatment for stage IB1 cervical cancer. RESULTS: Overall, 18 (15.0%) patients had parametrial tumor involvement. Tumor size larger than 2 cm, invasion depth greater than 1 cm, presence of lymphovascular space involvement (LVSI), corpus involvement, and positive lymph nodes were statistically associated with parametrial involvement. Multivariate analysis for other factors showed invasion depth >1 cm (P=0.029), and corpus involvement (P=0.022) were significantly associated with parametrial involvement. A subgroup with tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. CONCLUSION: Tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. Invasion depth >1 cm and corpus involvement were significantly associated with parametrial involvement in multivariate analysis. These finding may suggest that tumor size may a strong predictor of parametrial involvement in International Federation of Gynecology and Obstetrics stage IB1 cervical cancer, which can be used to select a subgroup population for less radical surgery.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Uterine Cervical Neoplasms
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Multivariate Analysis
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Retrospective Studies
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Cohort Studies
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Gynecology
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Hysterectomy
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Lymph Node Excision
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Lymph Nodes
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Obstetrics
نوع الدراسة:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
En
مجلة:
Obstetrics & Gynecology Science
السنة:
2018
نوع:
Article