Bacterial Infections after Liver Transplantation in Children: Single Center Study for 16 Years
Pediatric Infection & Vaccine
; : 82-90, 2018.
Article
ي Ko
| WPRIM
| ID: wpr-741856
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
Survival after liver transplantation (LT) has improved over the years, but infection is still a major complication. We aimed to identify the characteristics of bacterial infections in pediatric LT recipients.METHODS:
This study is a retrospective review of 189 consecutive children undergoing LT between 2000 and 2015 at a single center. In this study, the incidence of infection was determined for the following periods within 1 month, between 1–5 months, and between 6–12 months. Patients who underwent liver transplants more than once or multiple organ transplants were excluded.RESULTS:
All patients had received postoperative antibiotic for 3 days. Only the maintenance immunosuppression with oral tacrolimus and steroids were performed. As a result, 132 bacterial infections developed in 87 (46.0%) patients (0.70 events per person-year). Bacterial infections occurred most frequently within the first month (n=84, 63.6%) after LT. In the pathogens, Staphylococcus aureus (15.2%), Enterococcus species (15.2%), and Klebsiella species (13.6%) were most common. Regarding the organ infected, bloodstream was most common (n=39, 29.5%), followed by peritoneum (n=28, 21.2%), urinary tract (n=25, 18.9%), and lungs (n=20, 15.2%). We changed prophylactic antibiotics from ampicillin-sulbactam to piperacillin-tazobactam at 2011, October, there were no significant effects in the prevalence of antibiotics resistant bacterial infections. The 1-year mortality was 9.0% (n=17), in which 41.2% (n=7) was attributable to bacterial infection; septicemia (n=4), pneumonia (n=2), and peritonitis (n=1).CONCLUSIONS:
The incidence and type of bacterial infectious complications after LT in pediatric patients were similar to those of previous studies. Bacterial complications affecting mortality occur within 6 months after transplantation, so proper prophylaxis and treatment in this period may improve the prognosis of LT.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Peritoneum
/
Peritonitis
/
Pneumonia
/
Prognosis
/
Staphylococcus aureus
/
Steroids
/
Bacterial Infections
/
Urinary Tract
/
Incidence
/
Prevalence
نوع الدراسة:
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Child
/
Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
Ko
مجلة:
Pediatric Infection & Vaccine
السنة:
2018
نوع:
Article