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Research progress in hypogonadism of patients with β-thalassemia major / 国际儿科学杂志
Article ي Zh | WPRIM | ID: wpr-751483
المكتبة المسؤولة: WPRO
ABSTRACT
Hypogonadism is one of the most common endocrine complications in patients with β-thalassemia major (β-TM).It can be clinically characterized by pubertal developmental delay,primary or secondary amenorrhea infertility that would significantly compromises the quality of life of patients with β-TM.Its pathogenesis is complex and may be related to long-term anemia,iron overload,decreased leptin levels,chronic liver disease,transplant pretreatment drugs and so on.Regular monitoring and active intervention are crucial for promoting adolescent development,sexual function maturation and retention of fertility in β-TM patients.However,there is no relevant guidelines and consensus in our country to guide clinicians on the followup of gonadal function in β-TM patients.This review aims to summarize the research progress in hypogonadism of patients with β-TM in order to improve the level of prevention and treatment.
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النص الكامل: 1 الفهرس: WPRIM نوع الدراسة: Guideline اللغة: Zh مجلة: International Journal of Pediatrics السنة: 2019 نوع: Article
النص الكامل: 1 الفهرس: WPRIM نوع الدراسة: Guideline اللغة: Zh مجلة: International Journal of Pediatrics السنة: 2019 نوع: Article