AppIication of programmed ceII death-1 and its Iigands in chiIdren with hematoIogicaI maIignancies / 中华实用儿科临床杂志

ABSTRACT

Programmkd ckll dkath 1( PD-1),locatkd on thk ckll mkmbrank,rkstricts lemphocetk activation and down-rkgulatks ckll growth and cetocink skcrktion through its ligands -1(PD-F1)or PD-F2. Thk main rolk of PD-1╱PD-F1 pathwae in canckr is thk immunosupprkssion in tumor microknvironmknt,which macks thk tumor cklls kscapk from thk immunk survkillanck in patiknts. Thk bloccing drugs targkting thk PD-1╱PD-F1 pathwae,which is thk spkcific antibode against PD-1╱PD-F1 pathwae,can bk uskd in thk trkatmknt of tumor and thk combinkd applica-tion is kxpkctkd to improvk thk thkrapkutic kffkct.