TheapplicationofdexmedetomidinecombinedwithketamineandchloralhydrateinpediatricMRIscansedation / 实用放射学杂志

ABSTRACT

Objective Toexplorethesedativeeffectsandsafetyofdexmedetomidinewithketaminemixturenasaldropsbesideschloralhydrateoral andenemainchildren MRIexamination.Methods 619children (Group A)weresedatedbydexmedetomidinewithketamine,289 children(GroupB)weresedatedbychloralhydrateenemaand417childrenweresedatedbyoralchloralhydrate(GroupC)respectivelyinour hospital.ThelatestRamsaysedationscorewasadoptedtodeterminethesedationdepth.Thesedationscores,inductiontime,examinationtimeand recoverytimewererecordedrespectivelybeforeinduction,afterinductionandafterawakening.Results (1)Theinductiontimeof dexmedetomidinewithketaminewassignificantlyshorterthanchloralhydrate,anditsdifferencewasofstatisticmeaning(P<0.05). (2)ThesuccessrateofexaminationinGroupAwas100%;groupB61.6%;GroupC65.2%.ThesuccessrateofgroupAwassignificantlyhigher thanthatinbothgroupBandgroupC,thusthedifferencewasalsostatisticallysignificant.Conclusion AllmethodsaresafeforpediatricMRIat appropriatesedationdepth.Thesedativefailurerateofchloralhydrateishigher.Theinductionandawakeningtimeofdexmedetomidinewith ketaminemixturedropsisrelativelyshorter,thereforeithasgoodsedativeeffectintheMRIexamination.