Atg7 in development and disease: panacea or Pandora's Box?
Protein & Cell
; (12): 722-734, 2015.
Article
ي En
| WPRIM
| ID: wpr-757184
المكتبة المسؤولة:
WPRO
ABSTRACT
Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation. Thus, Atg7 stands at the hub of these two ubiquitin-like systems involving LC3 and Atg12 in autophagic vesicle expansion. In this review, I focus on the pleiotropic function of Atg7 in development, maintenance of health, and alternations of such control in disease.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Organ Specificity
/
Species Specificity
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Disease
/
Ubiquitin-Activating Enzymes
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Growth and Development
/
Metabolism
المحددات:
Animals
/
Humans
اللغة:
En
مجلة:
Protein & Cell
السنة:
2015
نوع:
Article