Proton transfer-mediated GPCR activation
Protein & Cell
; (12): 12-17, 2015.
Article
ي En
| WPRIM
| ID: wpr-757629
المكتبة المسؤولة:
WPRO
ABSTRACT
G-protein coupled receptors (GPCRs) play essential roles in signal transduction from the environment into the cell. While many structural features have been elucidated in great detail, a common functional mechanism on how the ligand-binding signal is converted into a conformational change on the cytoplasmic face resulting in subsequent activation of downstream effectors remain to be established. Based on available structural and functional data of the activation process in class-A GPCRs, we propose here that a change in protonation status, together with proton transfer via conserved structural elements located in the transmembrane region, are the key elements essential for signal transduction across the membrane.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Protons
/
Signal Transduction
/
Chemistry
/
Amino Acid Motifs
/
Receptors, G-Protein-Coupled
/
Membrane Potentials
/
Membrane Proteins
/
Metabolism
المحددات:
Humans
اللغة:
En
مجلة:
Protein & Cell
السنة:
2015
نوع:
Article