Sub-morbid dehydration-associated glomerular hyperfiltration: An emerging reality?
Kidney Research and Clinical Practice
; : 196-204, 2019.
Article
ي En
| WPRIM
| ID: wpr-758990
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: Severe dehydration decreases renal perfusion. However, it is unclear whether sub-morbid dehydration affects kidney function similarly. Although there have been numerous animal and human studies that have suggested mild dehydration is associated with glomerular hyperfiltration, it has not been confirmed on a large-scale in the general population. Therefore, we aimed to identify the relationship between hydration status and kidney function. METHODS: We reviewed the data of 28,342 adults who participated in the Korea National Health and Nutrition Examination Surveys. Urine specific gravity unit (SGU) was the primary variable that indicated hydration status, and the estimated glomerular filtration rate (eGFR) was used as the primary outcome. RESULTS: Multivariate linear regression analysis showed urine SGU was positively associated with eGFR, which was J-shaped in the multivariate generalized additive model plot. In the penalized spline curve analysis, the odds ratio for high eGFR was steadily increased. Although increased urine SGU was associated with decreased blood pressure and pulse rate, it had no effect on increased fasting glucose and total cholesterol, suggesting conflicting cardio-metabolic dehydration effects. CONCLUSION: Dehydration, presumably sub-morbid in an ambulatory community-dwelling general population, is associated with higher kidney function. The clinical significance of sub-morbid dehydration-associated glomerular hyperfiltration needs further investigation.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Perfusion
/
Specific Gravity
/
Blood Pressure
/
Linear Models
/
Odds Ratio
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Cholesterol
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Fasting
/
Dehydration
/
Renal Insufficiency, Chronic
/
Glomerular Filtration Rate
نوع الدراسة:
Etiology_studies
/
Prognostic_studies
المحددات:
Animals
/
Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Kidney Research and Clinical Practice
السنة:
2019
نوع:
Article