Evaluation of Metabolite Changes in the Occipital Cortex of Patients with Idiopathic Infantile Nystagmus or Bilateral Ametropic Amblyopia by Magnetic Resonance Spectroscopy
Korean Journal of Ophthalmology
; : 406-413, 2019.
Article
ي En
| WPRIM
| ID: wpr-760061
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
To evaluate the effects of idiopathic infantile nystagmus (IN) and bilateral ametropic amblyopia on metabolites in the occipital cortex by magnetic resonance spectroscopy.METHODS:
The children included in this prospective study were divided into three groups. Group 1 consisted of 11 patients with idiopathic IN, group 2 consisted of 10 patients with bilateral ametropic amblyopia and group 3 consisted of nine normal children. A single-voxel magnetic resonance spectroscopy examination was performed by placing a region of interest on the occipital cortex of each participant. N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho) concentrations were measured in the occipital cortex. This was followed by calculating and comparing the NAA/Cr and Cho/Cr ratios between the three groups. The Kruskal-Wallis test, Mann-Whitney U-test, and chi-square test were used for statistical analysis.RESULTS:
There was no statistically significant difference in NAA/Cr ratios between patients with idiopathic IN and normal children, but there was a statistically significant difference between these groups when Cho/Cr ratios were compared; the ratio was higher in the idiopathic IN group. There were no statistically significant differences in NAA/Cr or Cho/Cr ratios between patients with bilateral ametropic amblyopia and normal children.CONCLUSIONS:
Our findings suggest that the neurochemical profile of the occipital cortex is partially affected by idiopathic IN, but not by bilateral ametropic amblyopia.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Magnetic Resonance Spectroscopy
/
Amblyopia
/
Choline
/
Prospective Studies
/
Aspartic Acid
/
Creatine
/
Occipital Lobe
نوع الدراسة:
Observational_studies
المحددات:
Child
/
Humans
اللغة:
En
مجلة:
Korean Journal of Ophthalmology
السنة:
2019
نوع:
Article