Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
Natural Product Sciences
; : 244-247, 2019.
Article
ي En
| WPRIM
| ID: wpr-760565
المكتبة المسؤولة:
WPRO
ABSTRACT
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC₅₀ value of 13.1 µg/mL.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Stilbenes
/
HeLa Cells
/
Doxorubicin
/
Euphorbiaceae
/
Flavanones
المحددات:
Humans
اللغة:
En
مجلة:
Natural Product Sciences
السنة:
2019
نوع:
Article