Incidence and Risk Factors of Recurrent Venous Thromboembolism after Pulmonary Embolism / 결핵
Tuberculosis and Respiratory Diseases
; : 341-347, 2019.
Article
ي En
| WPRIM
| ID: wpr-761957
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: Information about the epidemiology of venous thromboembolism (VTE) recurrence in Korea is lacking. The purpose of this study was to investigate VTE cumulative recurrence rates and identify risk factors for VTE recurrence among Korean adults. METHODS: A retrospective cohort study was conducted on adult patients (≥18 years) admitted to a university teaching hospital for pulmonary embolism (PE) from 2005 to 2013. The main outcome of interest was a recurrence of VTE. We used Cox proportional hazard regression analyses to calculate the relative risk of VTE recurrence. RESULTS: Five-year cumulative incidence of recurrent VTE events was 21.5% (95% confidence interval [CI], 17.7–25.4) in all cases of PE; 17% after provoked and 27% after unprovoked PE. Multivariate analysis showed that body mass index (BMI) of ≥25 (hazard ratio [HR], 2.02; 95% CI, 1.17–3.46; p=0.01) and longer anticoagulation therapy duration (HR, 0.90; 95% CI, 0.84–0.96; p<0.01) were independently associated with risk of VTE recurrence. Risk factors not found to be statistically significant at the <0.05 level included history of VTE (HR, 1.81; 95% CI, 0.84–3.88; p=0.12), unprovoked PE (HR, 1.70; 95% CI, 0.89–3.25; p=0.10), symptomatic deep vein thrombosis (HR, 1.62; 95% CI, 0.89–2.94; p=0.10), and female sex (HR, 1.42; 95% CI, 0.78–2.55; p=0.24). We found that age, history of cancer, and other co-morbidities did not significantly affect the risk of VTE recurrence. CONCLUSION: Recurrence of VTE after PE is high. Patients with BMI ≥25 or reduced anticoagulation therapy duration have a higher risk of recurrent VTE.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pulmonary Embolism
/
Recurrence
/
Body Mass Index
/
Epidemiology
/
Incidence
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Multivariate Analysis
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Retrospective Studies
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Risk Factors
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Cohort Studies
/
Venous Thrombosis
نوع الدراسة:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Adult
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Female
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Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Tuberculosis and Respiratory Diseases
السنة:
2019
نوع:
Article