Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model
Biomolecules & Therapeutics
; : 457-465, 2019.
Article
ي En
| WPRIM
| ID: wpr-763036
المكتبة المسؤولة:
WPRO
ABSTRACT
Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in DM skin disorders, we quantitated 49 lipids (34 ceramides, 14 free fatty acids (FFAs), and cholesterol) in the skin epidermis, liver, and kidneys of db/db mice, a Type 2 DM model, using UPLC-MS/MS. The expression of genes involved in lipid synthesis was also evaluated. With the full establishment of hyperglycemia at the age of 20 weeks, remarkable lipid enrichment was noted in the skin of the db/db mice, especially at the epidermis and subcutaneous fat bed. Prominent increases in the ceramides and FFAs (>3 fold) with short or medium chains (Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Skin
/
Stearoyl-CoA Desaturase
/
Ceramides
/
Receptors, Cytoplasmic and Nuclear
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Diabetes Mellitus
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Diabetes Mellitus, Type 2
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Epidermis
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Subcutaneous Fat
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Fatty Acids, Nonesterified
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Hyperglycemia
المحددات:
Animals
/
Humans
اللغة:
En
مجلة:
Biomolecules & Therapeutics
السنة:
2019
نوع:
Article