Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population
The Korean Journal of Internal Medicine
; : 719-726, 2015.
Article
ي En
| WPRIM
| ID: wpr-76671
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND/AIMS: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population. METHODS: Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction. RESULTS: Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 x 10(-5)). CONCLUSIONS: We have identified polymorphisms associated with telomere length in a Korean population.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Phenotype
/
Case-Control Studies
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Zinc Fingers
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Telomere
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Telomerase
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Polymorphism, Single Nucleotide
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Asian People
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DNA-Binding Proteins
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Kruppel-Like Transcription Factors
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Genome-Wide Association Study
نوع الدراسة:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Adult
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Aged
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Female
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Humans
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Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
The Korean Journal of Internal Medicine
السنة:
2015
نوع:
Article