Chemical and cytotoxic constituents of Zanthoxylum nitidum / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4659-4664, 2018.
Article
ي Zh
| WPRIM
| ID: wpr-771536
المكتبة المسؤولة:
WPRO
ABSTRACT
Ten compounds were isolated from the methanol extract of Zanthoxylum nitidum through silica gel, Sephadex LH-20, RP-18 and HPLC chromatography techniques. Their structures were elucidated by the MS and NMR spectra as zanthonitidine B(1), cyclo-(Leu-Leu-Leu-Leu-Ile)(2),6S-10-O-demethylbocconoline(3), liriodenine(4), isoplatydesmine(5), 5, 5'-dimethoxylariciresinol(6), syringaresinol (7), episyringaresinol (8), marmesin (9) and syringaldehyde (10). Among them,1 is a new alkaloid,2 is a cyclopentapeptide isolated from plant kingdom for the first time, and 3 is from the genus Zanthoxylum for the first time. Compounds 3 and 4 exhibited cytoxoxicity against three human cancer cell lines HT29, A549 and MDA-MB-231 with IC₅₈ values of 27.37, 24.10, 33.58 μmol·L⁻¹ and 9.12,6.05, 11.35 μmol·L⁻¹, respectively.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Chromatography, High Pressure Liquid
/
Zanthoxylum
/
Alkaloids
المحددات:
Humans
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2018
نوع:
Article