Symptomatic Profiles of 173 Chinese Patients with Essential Thrombocythemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 520-526, 2019.
Article
ي Zh
| WPRIM
| ID: wpr-771926
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To explore the symptomatic burden of patients with essential thrombocythemia (ET) and its relation with clinical characteristics including the mutation status, therapeutic protocols and sex.@*METHODS@#Total of 173 Chinese ET patients were selected and grouped on the basis of disease characteristics (mutation status, therapeutic pro to- cols, and sex).@*RESULTS@#All the groups showed low-to-high symptom burden, with the highest in the Hu (hydroxyurea)-group (total symptom score [TSS], 14.7; range, 7.6-14.7). In the JAK2V617F-positive, Hu-treated, and female groups TSS and independent symptom scores were higher than those in the control group. The CALR-positive and IFN-α-treated groups had lower overall and individual scores as compared with groups lacking the corresponding characteristics. As the number of characteristics (JAK2V617F-positive, Hu-treated, and female) increases, the severity of symptoms gradually increased.@*CONCLUSION@#The different characteristics have various effects on symptom burden in ET patients. The accumulation of certain characteristics will lead to more severe symptom burden, thus the patient's symptom burden should be considered comprehensively when making up the treatment schemes and prognosis.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Calreticulin
/
Asian People
/
Janus Kinase 2
/
Thrombocythemia, Essential
/
Hydroxyurea
/
Mutation
نوع الدراسة:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
المحددات:
Female
/
Humans
اللغة:
Zh
مجلة:
Journal of Experimental Hematology
السنة:
2019
نوع:
Article