Study on effect of extract from Tibetan medicine Urtica hyperborean on anti-prostatic hyperplasia / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1953-1959, 2019.
Article
ي Zh
| WPRIM
| ID: wpr-773143
المكتبة المسؤولة:
WPRO
ABSTRACT
In this study,mouse models of benign prostatic hyperplasia induced by subcutaneous injection of testosterone propionate was used to investigate the therapeutic effect and mechanism of Urtica hyperborean( UW) extracts on prostate hyperplasia in mice. The effects of UW extracts on prostate index,serum epidermal growth factor( EGF) and dihydrotestosterone( DHT) in model mice were observed,and the EGF and anti-apoptotic factor( Bcl-2) mRNA expression levels were detected as well as pathological changes in prostate tissue. The results showed that the ethyl acetate extraction and alcohol soluble fraction of the UW could significantly reduce the prostate index,reduce the serum DHT and EGF levels( P<0. 01),and significantly decrease the EGF and Bcl-2 mRNA expression( P<0. 01),significantly improved the morphological structure of prostate tissue. The above results confirmed that ethyl acetate extract and alcohol-soluble parts of UW have a good preventive effect on mice prostatic hyperplasia model,and its mechanism may be to reduce androgen levels by regulating polypeptide growth factors and/or inhibiting cell hyperproliferation and promoting apoptosis. This study laid the foundation for the further research on UW.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Prostatic Hyperplasia
/
Dihydrotestosterone
/
Blood
/
Plant Extracts
/
Chemistry
/
Proto-Oncogene Proteins c-bcl-2
/
Urticaceae
/
Medicine, Tibetan Traditional
/
Testosterone Propionate
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2019
نوع:
Article