Investigation on intestinal absorption ingredients and their absorption characteristics in Pterocephali Herba by everted intestinal sac method / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3170-3177, 2019.
Article
ي Zh
| WPRIM
| ID: wpr-773736
المكتبة المسؤولة:
WPRO
ABSTRACT
The intestinal absorption characteristics of ten iridoid glycosides and phenolic acids in the Pterocephali Herba were evaluated via rat intestinal valgus model. The intestinal sac fluids at different time after administration of high,medium and low concentrations of Pterocephali Herba extract were collected and ten chemical components in fluid samples were detected by UPLC-PDA. Accumulative absorbed doses( Q) and absorption rate constants( Ka) of ten chemical constituents were calculated,while proportions between Pterocephali Herba extract and intestinal absorption liquid were compared. The results showed that the intestinal absorption of 10 chemical components was linear absorption( R2>0. 9) at different concentrations,which accorded with the zero-order absorption rate. The absorption rate constant was related to the concentration of the drug and the intestinal site,which indicated that intestinal adsorption mechanism of the components were passive diffusion and active transport. Proportions of chemical constituents in intestinal sac fluid were different from those in Pterocephali Herba extract. Therefore,those ten chemical components in Pterocephali Herba extract can be absorbed in whole intestine. Everted intestinal sac model can be used to evaluate intestinal absorption characteristics of ingredients in Pterocephali Herba extract effectively.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Plant Extracts
/
Chemistry
/
Rats, Sprague-Dawley
/
Caprifoliaceae
/
Intestinal Absorption
/
Intestines
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2019
نوع:
Article