Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
Acta Pharmaceutica Sinica B
; (6): 144-156, 2019.
Article
ي En
| WPRIM
| ID: wpr-774995
المكتبة المسؤولة:
WPRO
ABSTRACT
Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
En
مجلة:
Acta Pharmaceutica Sinica B
السنة:
2019
نوع:
Article