Expression of Nod-like receptor protein 3 inflammasome in peripheral blood mononuclear cells of children with Kawasaki disease in the acute stage / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 992-997, 2019.
Article
ي Zh
| WPRIM
| ID: wpr-775068
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To study the association of Nod-like receptor protein 3 (NLRP3) inflammasome with inflammatory response in the acute stage and coronary artery lesion (CAL) in children with Kawasaki disease (KD).@*METHODS@#A total of 42 children with KD who were hospitalized from January to October 2017 were enrolled as the KD group, among whom 9 had CAL (CAL group) and 33 had no CAL (NCAL group). Fifteen age- and gender-matched children with pneumonia and pyrexia were enrolled as the pneumonia-pyrexia group. Fifteen healthy children were enrolled as the healthy control group. Real-time PCR was used to measure the mRNA expression of NLRP3 inflammasome (NLRP3, ASC and caspase-1) in peripheral blood mononuclear cells. The Spearman rank correlation test was used to investigate the correlation of NLRP3 mRNA expression with serum levels of C-reactive protein, erythrocyte sedimentation rate, interleukin-6, interleukin-1β, procalcitonin, albumin and prealbumin.@*RESULTS@#The KD group had significantly higher mRNA expression of NLRP3, ASC and caspase-1 in the acute stage than the pneumonia-pyrexia and healthy control groups (P<0.05). The CAL group had significantly higher mRNA expression of NLRP3 than the NCAL group (P<0.05). NLRP3 mRNA expression was correlated with C-reactive protein, interleukin-6, interleukin-1β, and prealbumin levels in children with KD in the acute stage (r=0.449, 0.376, 0.427, and -0.416 respectively; P<0.05).@*CONCLUSIONS@#NLRP3 inflammasome may participate in inflammatory response in the acute stage and the development of CAL in children with KD.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Leukocytes, Mononuclear
/
Interleukin-1beta
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Inflammasomes
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NLR Family, Pyrin Domain-Containing 3 Protein
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Metabolism
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Mucocutaneous Lymph Node Syndrome
المحددات:
Child
/
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Contemporary Pediatrics
السنة:
2019
نوع:
Article