Progress of Bevacizumab in Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 118-124, 2019.
Article
ي Zh
| WPRIM
| ID: wpr-775655
المكتبة المسؤولة:
WPRO
ABSTRACT
Lung cancer is the most commonly diagnosed cancer worldwide. Malignant pleural effusion (MPE) caused by advanced lung cancer seriously affect the patients' quality of life and prognosis. The management of MPE includes thoracentesis, pleurodesis, indwelling pleural catheters and drug perfusion in pleural cavity. Vascular endothelial growth factor (VEGF) and its receptor are a group of important ligands and receptors that affect angiogenesis. They are the main factors controlling angiogenesis, and they play an important role in the formation of MPE. Bevacizumab is a recombinant humanized VEGF monoclonal antibody, competitively binding to endogenous VEGF receptor. Bevacizumab can inhibit new blood vessel formation, reduce vascular permeability, prevent pleural effusion accumulation and slow the growth of cancers. This review aims to discuss the progress of bevacizumab in the treatment of MPE caused by non-small cell lung cancer (NSCLC), and explore the clinical application, efficacy, safety and future direction of bevacizumab.
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Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Pleural Neoplasms
/
Pleural Effusion, Malignant
/
Carcinoma, Non-Small-Cell Lung
/
Therapeutic Uses
/
Drug Therapy
/
Antineoplastic Agents, Immunological
/
Antineoplastic Agents
نوع الدراسة:
Prognostic_studies
المحددات:
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Lung Cancer
السنة:
2019
نوع:
Article