Effects of Mitochondrial Dysfunction via AMPK/PGC-1 α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 386-394, 2019.
Article
ي En
| WPRIM
| ID: wpr-776594
المكتبة المسؤولة:
WPRO
ABSTRACT
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1 α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1 α pathway and improving mitochondrial function.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Signal Transduction
/
Neuroprotective Agents
/
Therapeutic Uses
/
Diabetic Neuropathies
/
Drug Therapy
/
AMP-Activated Protein Kinases
/
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/
Medicine, Chinese Traditional
/
Metabolism
نوع الدراسة:
Diagnostic_studies
المحددات:
Humans
اللغة:
En
مجلة:
Chinese journal of integrative medicine
السنة:
2019
نوع:
Article