Withaminimas A-F, six withanolides with potential anti-inflammatory activity from Physalis minima / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 469-474, 2019.
Article
ي En
| WPRIM
| ID: wpr-776864
المكتبة المسؤولة:
WPRO
ABSTRACT
Withaminimas A-F (1-6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2-3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1-4 exhibited significant inhibitory effects with IC values among 3.91-18.46 μmol·L.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Structure-Activity Relationship
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
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Lipopolysaccharides
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Physalis
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Allergy and Immunology
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Withanolides
/
Macrophages
المحددات:
Animals
اللغة:
En
مجلة:
Chinese Journal of Natural Medicines (English Ed.)
السنة:
2019
نوع:
Article