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Prevalence of hepatitis C virus infection and the IL28B genotype polymorphism among blood donors and high-risk populations
Singap. med. j ; Singap. med. j;: 34-39, 2019.
Article ي En | WPRIM | ID: wpr-777551
المكتبة المسؤولة: WPRO
ABSTRACT
INTRODUCTION@#To study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive.@*METHODS@#The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least six months of follow-up between January 2009 and December 2014. IVDU population was from inmates at halfway houses who consented.@*RESULTS@#Between 2011 and 2014, of 161,658 individuals who underwent screening prior to blood donation, 95 (0.059%) were positive for HCV. Of the 42 sera available, common genotypes (GTs) were GT-3 (47.6%) and GT-1 (31.0%). Of 1,575 HD patients, 2.2% were anti-HCV positive. The HCV GT distribution was HCV GT-1 (32.4%), HCV GT-3 (20.5%) and GT-6 (8.8%). 83 halfway house inmates were screened. Of the 47 IVDUs, 36.2% were anti-HCV positive with predominant GT-3 (%). IL28B polymorphism was noted to be CC predominantly 85.3%.@*CONCLUSION@#Prevalence of HCV infection has decreased in both the BD and HD populations. However, it remains high in the IVDU population. GT-1 remains the most common in the HD population; however, GT-3 infection is now more common among the BD population in Singapore. IL28B - CC is the predominant variant among the HCV-infected individuals in Singapore.
الموضوعات
Key words
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Singapore / Blood / Blood Donors / Substance Abuse, Intravenous / Epidemiology / Prevalence / Renal Dialysis / Interleukins / Hepatitis C / Polymorphism, Single Nucleotide نوع الدراسة: Etiology_studies / Prevalence_studies / Risk_factors_studies المحددات: Adult / Female / Humans / Male البلد/الأقليم حسب الموضوع: Asia اللغة: En مجلة: Singap. med. j السنة: 2019 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Singapore / Blood / Blood Donors / Substance Abuse, Intravenous / Epidemiology / Prevalence / Renal Dialysis / Interleukins / Hepatitis C / Polymorphism, Single Nucleotide نوع الدراسة: Etiology_studies / Prevalence_studies / Risk_factors_studies المحددات: Adult / Female / Humans / Male البلد/الأقليم حسب الموضوع: Asia اللغة: En مجلة: Singap. med. j السنة: 2019 نوع: Article