Anti-inflammatory effect of recombinant human kallistatin in ulcerative colitis of mice / 药学学报
Acta Pharmaceutica Sinica
; (12): 1077-2016.
Article
ي Zh
| WPRIM
| ID: wpr-779279
المكتبة المسؤولة:
WPRO
ABSTRACT
This study was designed to evaluate the anti-inflammatory effect of recombinant human kallistatin (Kal) on ulcerative colitis (UC) in the mouse model. Acute colitis was induced by administration of 4% dextran sodium suffate (DSS) to KM mice for 7 days. The mice were then randomized into 5 groupsmodel control, Kal 0.2 mg·kg-1·d-1, 1.0 mg·kg-1·d-1 and 2.0 mg·kg-1·d-1 group, salazosulfapyridine (SASP) group. Ten age-matched normal KM mouse were administered with saline in the normal control. The weight, colon length, inflammation factor (MPO/SOD/MDA) and TNF-α/IL-10 levels among the five groups of mice were determined. The results showed that histological index score and MPO/MDA/TNF-α levels of high-dose Kal treatment group and SASP group were significantly lower compared with the model group (PPα/IL-10 levels and has some antioxidant activity.
النص الكامل:
1
الفهرس:
WPRIM
نوع الدراسة:
Clinical_trials
/
Prognostic_studies
اللغة:
Zh
مجلة:
Acta Pharmaceutica Sinica
السنة:
2016
نوع:
Article