Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines / 한국실험동물학회지
Laboratory Animal Research
; : 180-186, 2019.
Article
ي En
| WPRIM
| ID: wpr-786405
المكتبة المسؤولة:
WPRO
ABSTRACT
In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very prevalent, causing treat harm to humans and animals in aspect of public health, and economical issues. The critical problem is that newly-reported infectious diseases that humans firstly experience are expected to continue to emerge, and these diseases will be spreading out rapidly. Therefore, rapid and safe supplies of effective vaccines are most pivotal to prevent the rapid prevalent of new infection, but international standards or assessing protocol the safety of urgent vaccines are not established well. In our previous study, since we established a module to assess the brain safety of urgent vaccines, therefore, it is necessary to verify that this established module for assessing brain safety could work effectively in commercially available two vaccines (one killed- and on live-vaccines). We compared the results of Evans blue (EB) assay and qPCR analysis by injection of two kinds of vaccines, PBS and Lipopolysaccharide (LPS) under the condition of the module previously reported. We confirmed that the brain safety test module for urgent vaccine we established is very reproducible. Therefore, it is believed that this vaccine safety testing method can be used to validate brain safety when prompt supply of a newly developed vaccines is needed.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Brain
/
Vaccines
/
Public Health
/
Communicable Diseases
/
Coronavirus Infections
/
Severe Acute Respiratory Syndrome
/
Equipment and Supplies
/
Evans Blue
/
Methods
المحددات:
Animals
/
Humans
اللغة:
En
مجلة:
Laboratory Animal Research
السنة:
2019
نوع:
Article