Prognosis of the central nervous system involvement in patients with hemophagocytic lymphohistiocytosis / 中华血液学杂志
Chinese Journal of Hematology
; (12): 848-852, 2017.
Article
ي Zh
| WPRIM
| ID: wpr-809454
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective@#To investigate the characteristics and prognostic factor of central nervous system (CNS) involvement in patients with hemophagocytic lymphohistiocytosis (HLH) .@*Methods@#From January 2006 to October 2015, 152 patients with HLH, 88 patients had CNS involvement, their clinical data were collected, and survival was analyzed using the Kaplan-Meier life table method, univariate and multivariate Cox regression model analyses were applied to identify the risk factors of prognosis.@*Results@#①57.9% patients complicated with neurological symptoms, cerebrospinal fluid abnormalities were observed in 37.0% patients, 57.5% patients had abnormal neuroradiology. ②36 patients survived well, 3 patients lost to follow-up, 49 dead, 1 survival patient had epilepsy. ③The 3-year overall survival rate of 88 patients was 44%. ④abnormal CSF and unreceived IT bore a significant, independent adverse prognostic value (P<0.05) .@*Conclusion@#CNS involvement in HLH has a high frequency and poor prognosis, few patients remained neurologic sequelae; abnormal CSF related to poor prognosis, positive intrathecal injections could improve the prognosis.
النص الكامل:
1
الفهرس:
WPRIM
نوع الدراسة:
Prognostic_studies
/
Risk_factors_studies
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2017
نوع:
Article