Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 540-545, 2017.
Article
ي En
| WPRIM
| ID: wpr-812083
المكتبة المسؤولة:
WPRO
ABSTRACT
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Staphylococcus aureus
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Plant Extracts
/
Microbial Sensitivity Tests
/
Chemistry
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Holarrhena
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Alkaloids
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Methicillin-Resistant Staphylococcus aureus
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Anti-Bacterial Agents
اللغة:
En
مجلة:
Chinese Journal of Natural Medicines (English Ed.)
السنة:
2017
نوع:
Article