Triterpenoid saponins from the roots of Cyathula officinalis and their inhibitory effects on nitric oxide production / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 463-466, 2017.
Article
ي En
| WPRIM
| ID: wpr-812093
المكتبة المسؤولة:
WPRO
ABSTRACT
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl-(1→3)-β-D-glucopyranosyl] hederagenin (1), was isolated from the roots of Cyathula officinalis. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages cells. Compounds 2, 4, and 6 exhibited moderate anti-inflammatory activities.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Saponins
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Triterpenes
/
Magnetic Resonance Spectroscopy
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Cells, Cultured
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Chemistry
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Plant Roots
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Amaranthaceae
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Anti-Inflammatory Agents
/
Nitric Oxide
المحددات:
Animals
اللغة:
En
مجلة:
Chinese Journal of Natural Medicines (English Ed.)
السنة:
2017
نوع:
Article