Chemical constituents from the stems of Gymnema sylvestre / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 300-304, 2014.
Article
ي En
| WPRIM
| ID: wpr-812260
المكتبة المسؤولة:
WPRO
ABSTRACT
AIM@#To study the chemical constituents of stems of Gymnema sylvestre (Retz.) Schult.@*METHODS@#Chromatographic techniques using silica gel, C18 reversed phase silica gel, and prep-HPLC were used. The structures were elucidated on the basis of MS and spectroscopic analysis (1D and 2D NMR), as well as chemical methods.@*RESULTS@#Seven compounds were isolated and their structures were elucidated as conduritol A (1), stigmasterol (2), lupeol (3), stigmasterol-3-O-β-D-glucoside (4), the sodium salt of 22α-hydroxy-longispinogenin-3-O-β-D-glucopyranosyl-(1→3)-β-D-glu-curono-pyranosyl-28-O-α-L-rhamnopyranoside (5), oleanolic acid-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (6), and the sodium salt of 22α-hydroxy-longispinogenin 3-O-β-D-glucuronopyranosyl-28-O-α-L-rhamnopyranoside (7). The inhibition activities of compounds 1, 5-7 on non-enzymatic glycation of protein in vitro were evaluated.@*CONCLUSION@#Compound 7 is a new triterpenoid saponin. It was shown that compounds 1, 5-7 have weak inhibition activities for non-enzymatic glycation of protein in vitro.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Plant Stems
/
Gymnema sylvestre
اللغة:
En
مجلة:
Chinese Journal of Natural Medicines (English Ed.)
السنة:
2014
نوع:
Article