Gene polymorphisms of estrogen receptor α correlated with hypospadias in children / 中华男科学杂志
National Journal of Andrology
; (12): 61-64, 2017.
Article
ي Zh
| WPRIM
| ID: wpr-812809
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective@#To investigate the association of the polymorphisms of the gene of estrogen receptor α 1 (ESR1) with the risk of hypospadias in children of Northeast China.@*METHODS@#This study included 95 hypospadias patients aged 3.2±0.6 years and 105 children aged 3.1±0.7 years as normal controls. Using PCR and gene sequencing, we determined the genotypes of the polymorphisms of ESR1 rs2077647 and rs6932902 in the two groups of subjects.@*RESULTS@#The results of PCR and gene sequencing showed statistically significant differences in the genotype and allele frequency distribution of the polymorphisms rs2077647 (χ2 = 8.552) and rs6932902 (χ2 = 16.251) (P<0.05) in the hypospadias and control groups. The hypospadias patients, in comparison with the normal controls, exhibited a markedly higher frequency of the SNP C allele in rs2077647 (OR = 1.410 [1.130-1.759], P<0.05), but a remarkably lower frequency of the SNP G allele in rs6932902 (OR = 2.263 [1.503-3.408], P<0.01).@*CONCLUSIONS@#The rs2077647 and rs6932902 polymorphisms of the ESR1 gene are associated with the risk of hypospadias, and so is its haplotype in children in Northeast China.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Haplotypes
/
Case-Control Studies
/
China
/
Risk
/
Polymorphism, Single Nucleotide
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Estrogen Receptor alpha
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Alleles
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Genetics
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Genotype
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Hypospadias
نوع الدراسة:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
المحددات:
Child, preschool
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Humans
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Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
Zh
مجلة:
National Journal of Andrology
السنة:
2017
نوع:
Article