Nontarget area and threshold selection in 99mTc-DTPA orbital SPECT/CT imaging inthyroid associated ophthalmopathy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 869-874, 2018.
Article
ي Zh
| WPRIM
| ID: wpr-813182
المكتبة المسؤولة:
WPRO
ABSTRACT
To compare diagnostic value of 4 kinds of target-to-nontarget ratio (T/NT), and to choose a better one to assess thyroid associated ophthalmopathy (TAO) activity.
Methods:
The clinical data were collected for 29 newly-diagnosed patients (58 eyes) with TAO who underwent orbital 99mTc-DTPA single photon emission computed tomography/computed tomography (SPECT/CT) fusion images according to the clinical activity score (CAS). They were divided into an active group (18 cases, 36 eyes), an inactive group (11 cases, 22 eyes), and a control group (9 cases, 18 eyes). Diagnostic value of orbital/occipital lobe radioactive uptake count ratio (T/NT1), orbital/occipital radioactive uptake count ratio (T/NT2), orbital/thalamus radioactive uptake count ratio (T/NT3), and orbital/cerebellar radioactivity uptake count ratio (T/NT4) were calculated, and the CAS of Spearman rank correlation and receiver operating characteristic (ROC) curve were analyzed.Results:
T/NT1, T/NT2 and CAS were correlated (r1=0.873, r2=0.527; P0.05). Area under the ROC curve of T/NT1 was 0.860, area under the ROC curve of T/NT2 was 0.581, and the accuracy for T/NT1 on TAO activity was good. T/NT1=9.74 could be used as active threshold for judge of TAO in patients.Conclusion:
There is a good correlation between T/NT1 and CAS. TAO activity assessment possesses high diagnostic value, and SPECT/CT together with imaging anatomical location is more accurate.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Orbit
/
Diagnostic Imaging
/
Case-Control Studies
/
Tomography, Emission-Computed, Single-Photon
/
ROC Curve
/
Technetium Tc 99m Pentetate
/
Statistics, Nonparametric
/
Radiopharmaceuticals
/
Graves Ophthalmopathy
/
Methods
نوع الدراسة:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
Zh
مجلة:
Journal of Central South University(Medical Sciences)
السنة:
2018
نوع:
Article