Association between elevated visfatin and carotid atherosclerosis in patients with chronic kidney disease / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 553-559, 2013.
Article
ي En
| WPRIM
| ID: wpr-814831
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To determine the levels of visfatin in patients with chronic kidney disease (CKD) and to explore the relationship between visfatin levels and caroid atherosclerosis in CKD patients.@*METHODS@#A total of 180 CKD patients (102 non-dialyzed patients and 78 dialysis patients) and 42 healthy subjects enrolled in this study. The serum levels of visfatin, IL-6, and high sensitive C-reactive protein (hsCRP) were measured by ELISA. Common carotid arteries intima-media thickness (CCA-IMT), cross-sectional calculated intima-media thickness (c IMT) area and atherosclerotic plaque were detected by non-invasive high-resolution B-mode ultrasonography.@*RESULTS@#The serum levels of visfatin, IL-6 and hsCRP were significantly increased in CKD patients compared with age matched healthy subjects (P<0.01). The serum levels of visfatin, IL-6 and hsCRP in the dialyzed patients were significantly higher than those in non-dialyzed patients (P<0.05). Visfatin levels increased with the progression of renal dysfunction and inversely related to creatinine clearance (Ccr) in non-dialyzed patients (r=-0.415, P<0.05). Patients with carotid artery plaques showed significantly higher levels of visfatin[(34.22±7.96) ng/mL)] compared with those without plaques [(28.24±6.18) ng/mL, P<0.05]. The serum levels of visfatin were closely correlated with IL-6 (r=0.548, P<0.001), hsCRP (r=0.430, P<0.001), CCA-IMT (r=0.462, P<0.05), and c IMT area (r=0.411, P<0.05). After adjusting for GFR, age, gender, and other risk factors associated with atherosclerosis, multiple stepwise regression analysis showed that serum visfatin is a independent risk factor for CCA-IMT (β=0.433, P<0.01) and c IMT area (β=0.412, P<0.01).@*CONCLUSION@#The serum level of visfatin increase with the progression of CKD and should be considered to be a new risk factor for atherosclerosis in CKD.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Blood
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C-Reactive Protein
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Carotid Artery Diseases
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Case-Control Studies
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Risk Factors
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Interleukin-6
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Renal Insufficiency, Chronic
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Nicotinamide Phosphoribosyltransferase
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Metabolism
نوع الدراسة:
Etiology_studies
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Observational_studies
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Risk_factors_studies
المحددات:
Adult
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Aged
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Female
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Humans
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Male
اللغة:
En
مجلة:
Journal of Central South University(Medical Sciences)
السنة:
2013
نوع:
Article