Immune pathogenesis of IgA nephropathy and its drugable targets / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 96-101, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-815455
المكتبة المسؤولة:
WPRO
ABSTRACT
IgA nephropathy (IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide. The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli. Dysregulation of the immune system plays an important role in the pathogenesis of IgAN. Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Immunoglobulin A
/
B-Lymphocytes
/
T-Lymphocytes
/
Chemistry
/
Glomerular Mesangium
/
Glomerulonephritis, IGA
/
Antigen-Antibody Complex
نوع الدراسة:
Etiology_studies
المحددات:
Humans
اللغة:
Zh
مجلة:
Journal of Central South University(Medical Sciences)
السنة:
2014
نوع:
Article