Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4
Asian Pacific Journal of Tropical Medicine
; (12): 732-738, 2013.
Article
ي En
| WPRIM
| ID: wpr-819975
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To analyze breast cancer bone metastasis related gene-CXCR4.@*METHODS@#This research screened breast cancer bone metastasis related genes by high-flux gene chip.@*RESULTS@#It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.@*CONCLUSIONS@#The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
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Bone Neoplasms
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Breast Neoplasms
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Molecular Sequence Data
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Gene Expression Regulation, Neoplastic
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Up-Regulation
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Chemistry
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Sequence Alignment
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Amino Acid Sequence
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Computational Biology
المحددات:
Adult
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Female
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Humans
اللغة:
En
مجلة:
Asian Pacific Journal of Tropical Medicine
السنة:
2013
نوع:
Article