Effect of Rougan Huaqian granules combined with human mesenchymal stem cell transplantation on liver fibrosis in cirrhosis rats
Asian Pacific Journal of Tropical Medicine
; (12): 576-581, 2014.
Article
ي En
| WPRIM
| ID: wpr-820679
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To observe the effect of Rougan Huaqian granules combined with human mesenchymal stem cell (hMSC) transplantation on the liver fibrosis in carbon tetrachloride-induced cirrhosis rats.@*METHODS@#Sixty SD rats were randomly divided into five groups. The rats in control group received intraperitoneal injection of saline, while those in model control group, treatment group A, group B and group C received intraperitoneal injection of carbon tetrachloride oily solution to induce liver cirrhosis within 8 weeks. Then, the rats in the model control group, treatment group A, treatment group B, treatment group C received vein tail injection of saline, Rougan Huaqian granules, hMSC suspension and Rougan Huaqian granules combined with hMSC suspension.@*RESULTS@#The treatment groups had significantly different liver function (AST levels), liver fibrosis index (laminin and HA), hepatic sinusoidal wallsα-smooth muscle actin, IV collagen and laminin protein expression and I, III collagen from the model group (P<0.05). The transplanted cells showed human hepatocyte-like cells differentiation trend in the liver.@*CONCLUSIONS@#The Rougan Huaqian granules combined with hMSC transplantation can alleviate liver fibrosis in cirrhosis rats.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Organ Size
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Pathology
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Pharmacology
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Therapeutics
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Body Weight
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Drugs, Chinese Herbal
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Chemistry
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Collagen
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Rats, Sprague-Dawley
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Therapeutic Uses
المحددات:
Animals
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Female
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Humans
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Male
اللغة:
En
مجلة:
Asian Pacific Journal of Tropical Medicine
السنة:
2014
نوع:
Article