Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease / 医学前沿
Frontiers of Medicine
; (4): 293-304, 2020.
Article
ي En
| WPRIM
| ID: wpr-827862
المكتبة المسؤولة:
WPRO
ABSTRACT
Netrin-1, an axon guidance factor, and its receptor UNC5B play important roles in axonal development and angiogenesis. This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis. Netrin-1 and UNC5B were upregulated in streptozotocininduced DKD Wistar rats, and their expression was compared with that in healthy controls. However, exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and tubulogenesis. This effect was likely associated with SRC pathway deactivation. Netrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced HRGECs. These results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in DKD. Therefore, introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD.
النص الكامل:
1
الفهرس:
WPRIM
نوع الدراسة:
Guideline
اللغة:
En
مجلة:
Frontiers of Medicine
السنة:
2020
نوع:
Article