Photothermal Effect-based Cytotoxic Ability of Melanin from Shells to Heal Wounds Infected with Drug-resistant Bacteria / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 471-483, 2020.
Article
ي En
| WPRIM
| ID: wpr-828990
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective@#Owing to antibiotic abuse and the subsequent development of antibiotic resistance, bacterial infection has become one of the most persistent unresolved problems. New antibacterial agents, especially those that are environmental-friendly, are urgently needed.@*Methods@#Melanin extracted by filtration centrifugation and acid and proteolytic hydrolysis was characterized using UV, FTIR, TEM, and XPS. Photothermal conversion was calculated, and the bacteriostatic effects, and , were assessed by plate counting and ratios (%) of wound areas.@*Results@#Natural melanin hydrolyzed by trypsin had good photothermal conversion effects, which resulted in superior bacteriostatic activities. The extracted melanin along with laser NIR irradiation at 808 nm promoted the healing of wounds infected by drug-resistant bacteria and was biocompatible according to toxicity tests and .@*Conclusion@#The present findings indicated a safe and efficient method of developing natural antibacterial agents.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Radiation Effects
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Staphylococcal Infections
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Staphylococcus aureus
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Wound Healing
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Chemistry
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Rats, Sprague-Dawley
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Drug Therapy
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Escherichia coli
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Escherichia coli Infections
المحددات:
Animals
اللغة:
En
مجلة:
Biomedical and Environmental Sciences
السنة:
2020
نوع:
Article