Molecular Characterization of a New Hantaan Virus Howang Strain
Journal of the Korean Society of Virology
; : 59-68, 1997.
Article
ي Ko
| WPRIM
| ID: wpr-83734
المكتبة المسؤولة:
WPRO
ABSTRACT
Hantaan virus Howang strain which isolated from the blood of severe case of Korean hemorrhagic fever is more virulent than HTN 76/118 and showed different RFLP from partial PCR amplified M genome segment to established Hantaan serotype viruses. We have determined the nucleotide sequence of the M and S genome segments and compared to HTN 76/118. The M and S segment of Howang strain has 3615 and 1696 nucleotides long, respectively. The M segment sequence of Howang strain is one mucleotide shorter than HTN 76/118. The sequence data of Howang strain shows 93.5% homology to HTN 76/118. One long open reading frame, which stoats from 41nt. to 3448nt. of the M segment and from 37nt. to 1326nt. of the S segment, exist to on complementary sense of the virus genome. There are no significant difference between HTN 76/118 and Howang strain on hydrophobicity of deduced polypeptides, but has slight difference on secondary structure.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Peptides
/
Polymorphism, Restriction Fragment Length
/
Base Sequence
/
Polymerase Chain Reaction
/
Open Reading Frames
/
Genome
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Hantaan virus
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Hydrophobic and Hydrophilic Interactions
/
Hemorrhagic Fever with Renal Syndrome
/
Nucleotides
اللغة:
Ko
مجلة:
Journal of the Korean Society of Virology
السنة:
1997
نوع:
Article