Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations
Experimental Neurobiology
; : 337-340, 2013.
Article
ي En
| WPRIM
| ID: wpr-84001
المكتبة المسؤولة:
WPRO
ABSTRACT
Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Recurrence
/
Seizures
/
Chest Pain
/
Limbic Encephalitis
/
Early Diagnosis
/
Diagnosis
/
Glioma
/
Memory
/
Nervous System Diseases
نوع الدراسة:
Diagnostic_studies
/
Screening_studies
المحددات:
Female
/
Humans
اللغة:
En
مجلة:
Experimental Neurobiology
السنة:
2013
نوع:
Article